Skip to main content

Grand Challenges Africa

How do you spur Science
Innovation and Entrepreneurship
in Africa?



The Grand Challenges Africa (GC Africa) programme seeks to promote Africa-led scientific innovations to help countries better achieve the Sustainable Development Goals by awarding seed and Scale-up grants to the continent’s most impressive solutions. It supports big, bold impactful innovative ideas that have the potential for impact, scale, and sustainability.

The focus for Grand Challenges Africa is not new academic research but impactful robust solutions and products from scientific research. GC Africa builds on the previous successes of local Grand Challenges programmes and a strong base of African Grand Challenges grantees. SFA Foundation implements GC Africa in partnership with the African Union Development Agency (AUDA-NEPAD) with the support of the Bill & Melinda Gates Foundation.

Grand Challenges Africa is part of the Grand Challenges family of initiatives, which seeks to engage innovators from around the world to solve science, technology and innovation, health, and developmental challenges. Grand Challenges initiatives are united by their focus on fostering innovation, directing research to where it will have the most impact, and serving those most in need.

The challenge also encourages partnerships that bring together investigators from diverse organizations, including for-profit institutions, non-governmental organizations, academic and health research institutions, foundations, and civil society groups. We believe that there is no unilateral access to ideas. Today, a variety of funding partners use “Grand Challenges” to accelerate research, creating an expanding network of funding and research partnerships spanning diverse topics. The Grand Challenges family includes the Bill and Melinda Gates Foundation, Grand Challenges Canada, United States Agency for International Development, Grand Challenges Brazil, Grand Challenges India, Grand Challenges South Africa, Grand Challenges Ethiopia, Grand Challenges Botswana, and Grand Challenges Africa.

Showing 11 - 20 of 25

Fortunate Mokoena, 2022

Identification of Novel Inhibitors Against Malarial and Trypanosomal Hsp90, GCA, South Africa

Fortunate Mokoena
North West University
South Africa

Identification of Novel Inhibitors Against Malarial and Trypanosomal Hsp90



Gabriel Mashabela, 2022

Utilization of Pathway-Selective Sensitized Mycobacterial CRISPRi Mutants to Generate High Quality Hits from Plant-Derived Natural Product Libraries, GCA, South Africa


Geoffrey Arunga, 2022

Applying Supervised Machine Learning to Develop an Adaptive Risk-Scoring Tool to Predict Maternal Morbidity and Adverse Pregnancy Outcomes, GCA, Kenya


Grace Mugumbate, 2022

Chemogenomic-Guided Identification and Optimization of Inhibitors of Plasmodium falciparum Heat Shock Proteins (PfHSPs) as Potential Anti-Malarial Drugs, GCA, Zimbabwe


Heinrich Hoppe, 2022

Novel Arf GTPase Assays for Antimalarial Drug Discovery, GCA, South Africa

Heinrich Hoppe
Rhodes University
South Africa

Novel Arf GTPase Assays for Antimalarial Drug Discovery



Iruka Okeke, 2022

Anti-Adhesins with Therapeutic Potential for Enteroaggregative Escherichia Coli Diarrhoea, GCA, Nigeria


Janine Aucamp, 2022

A 3D Clinostat-Based Bioreactor Model of Liver-Stage Plasmodium falciparum and its Applications in Parasite Biochemistry and Anti-Malarial Drug Discovery, GCA, South Africa


Joseph Akuze Waiswa, 2022

Improving Stillbirth and Neonatal Death Data Capture and Quality in Household Surveys: Big-Data Interdisciplinary Advances Using the Every Newborn-Indepth Multi-Country Survey Database, GCA, Uganda


Laurent Dembele, 2022

Identification of Compounds Targeting Specifically Plasmodium malariae Malaria for its Elimination Along with Plasmodium falciparum, GCA, Mali

Laurent Dembele
Université des Sciences, des Techniques et des Technologies de Bamako (USTTB)

Identification of Compounds Targeting Specifically Plasmodium malariae Malaria for its Elimination Along with Plasmodium falciparum



Lucas Malla, 2022

Novel Approaches for Modelling Gestational Weight Gain Trajectories Using the Super Imposition Translation and Rotation Growth Model for Predicting Neonatal Outcomes, GCA, Kenya