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Grand Challenges Africa

How do you spur Science
Innovation and Entrepreneurship
in Africa?



The Grand Challenges Africa (GC Africa) programme seeks to promote Africa-led scientific innovations to help countries better achieve the Sustainable Development Goals by awarding seed and Scale-up grants to the continent’s most impressive solutions. It supports big, bold impactful innovative ideas that have the potential for impact, scale, and sustainability.

The focus for Grand Challenges Africa is not new academic research but impactful robust solutions and products from scientific research. GC Africa builds on the previous successes of local Grand Challenges programmes and a strong base of African Grand Challenges grantees. SFA Foundation implements GC Africa in partnership with the African Union Development Agency (AUDA-NEPAD) with the support of the Bill & Melinda Gates Foundation.

Grand Challenges Africa is part of the Grand Challenges family of initiatives, which seeks to engage innovators from around the world to solve science, technology and innovation, health, and developmental challenges. Grand Challenges initiatives are united by their focus on fostering innovation, directing research to where it will have the most impact, and serving those most in need.

The challenge also encourages partnerships that bring together investigators from diverse organizations, including for-profit institutions, non-governmental organizations, academic and health research institutions, foundations, and civil society groups. We believe that there is no unilateral access to ideas. Today, a variety of funding partners use “Grand Challenges” to accelerate research, creating an expanding network of funding and research partnerships spanning diverse topics. The Grand Challenges family includes the Bill and Melinda Gates Foundation, Grand Challenges Canada, United States Agency for International Development, Grand Challenges Brazil, Grand Challenges India, Grand Challenges South Africa, Grand Challenges Ethiopia, Grand Challenges Botswana, and Grand Challenges Africa.

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Adeladza Kofi Amegah , 2022

Dietary and Environmental Mediators of Socio-Economic Inequalities in Child Undernutrition in West Africa, GCA, Ghana


Adrienne Edkins, 2022

The DnaJ-DnaK-GrpE Complex as a Selective Drug Target in Mycobacterium Tuberculosis, GCA, South Africa


Angela Dramoski, 2022

Modelling the Mortality Impact of Treatment Regimens for Antimicrobial-Resistant Neonatal Bloodstream Infections in 7 African Countries, GCA, South Africa


Anthony Ngugi, 2022

Optimizing Child Nutrition Investments for Increased Impact in High-Risk Populations in Kenya, GCA, Kenya


Chris Seebregts, 2022

Harnessing Data Science and Analytics to Strengthen Maternal, Newborn and Child Health Monitoring and Eliminate HIV Transmission in Low-Resource Settings, GCA, South Africa


Dinkorma Ouologuem, 2022

Identification of Plasmodium Falciparum Transmission Blocking Compounds, GCA, South Africa

Dinkorma Ouologuem
Université des Sciences, des Techniques et des Technologies de Bamako (USTTB)
South Africa

Identification of Plasmodium Falciparum Transmission Blocking Compounds




Edwin Murungi, 2022

Targeting Protein Kinases for the Development of Novel Drugs for Trematode Infections, GCA, Kenya


Elizabeth Kigondu, 2022

Identification of Novel Synthetic and Natural Product Semi-Synthetic Derivatives Targeting Mycobacterium smegmatis and M. tuberculosis Spectinomycin and Rifampicin Efflux Pumps, GCA, Kenya


Erick Strauss, 2022

Countering Anti-Microbial Resistance Through Chemical Manipulation of the Pathogen-Host Interaction, GCA, South Africa


Fabrice Boyom, 2022

Discovery of New Drug Candidates Against Malaria, Leishmaniasis and Trypanosomiasis Through Screening of Chemical Libraries, GCA, Cameroon